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. 2017 Mar 16;8:125. doi: 10.3389/fphar.2017.00125

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Copyright © 2017 Sharma, Levenson, Clements, Castella, Gebauer and Cox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histology of Reconstituted normal epidermal tissue vs reconstituted psoriatic tissue: H&E stained cross-sections showing reconstituted skin mimics normal epidermis organization and differentiation histology (A). The tissue morphology of the psoriatic tissue model closely parallels that of human psoriatic skin (B). The epidermis contains hyper proliferative basal keratinocytes stratum basale (Sb) with regular elongation of the rete ridges (psoriatic epidermal hyperplasia), and spinous (Ss), granular (Sg), and stratum corneum (Sc) layers. The dermis contains psoriatic fibroblasts (20X). Scale bar = 100 μm.