Table 2.
Correlation of the clinicopathological parameters with Dicer, Drosha, AGO2, and DGCR8 mRNA expression levels in Asian Korean PTC specimens.
| Dicer | P | Drosha | P | DGCR8 | P | AGO2 | P | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | Low | High | Low | High | |||||
| Age | 0.779a | 0.310c | 0.297a | 0.745c | ||||||||
| <40 | 9 | 5 | 7 | 7 | 12 | 2 | 8 | 6 | ||||
| 41–50 | 10 | 1 | 8 | 2 | 7 | 3 | 7 | 3 | ||||
| >50 | 9 | 6 | 9 | 7 | 11 | 5 | 11 | 5 | ||||
| T stage | 0.120a | 0.161a | 0.170a | 0.455a | ||||||||
| (1) | 16 | 5 | 14 | 7 | 14 | 7 | 12 | 9 | ||||
| (2) | 12 | 5 | 10 | 7 | 14 | 3 | 13 | 4 | ||||
| (3) | 0 | 2 | 0 | 2 | 2 | 0 | 1 | 1 | ||||
| N stage | 0.369b | 0.121c | 0.855c | 0.816c | ||||||||
| (+) | 12 | 7 | 9 | 10 | 14 | 5 | 12 | 7 | ||||
| (−) | 16 | 5 | 15 | 6 | 16 | 5 | 14 | 7 | ||||
| M stage | 1.000b | 0.400b | 1.000b | 1.000b | ||||||||
| (+) | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | ||||
| (−) | 28 | 12 | 24 | 15 | 29 | 10 | 25 | 14 | ||||
| Histologic stage |
0.562a | 0.215a | 0.609a | |||||||||
| (i) | 13 | 3 | 11 | 5 | 13 | 3 | 10 | 6 | ||||
| (ii) | 3 | 2 | 4 | 1 | 3 | 2 | 4 | 1 | ||||
| (iii) | 4 | 5 | 4 | 5 | 7 | 2 | 5 | 4 | ||||
| (iv) | 8 | 2 | 5 | 5 | 7 | 3 | 7 | 3 | ||||
| Extrathyroidal extension | 0.716b | 0.503b | 0.124b | 0.750c | ||||||||
| (+) | 18 | 9 | 15 | 12 | 18 | 9 | 18 | 9 | ||||
| (−) | 10 | 3 | 9 | 4 | 12 | 1 | 8 | 5 | ||||
| Bilateral lobe involvement |
0.677b | 0.690b | 0.388b | 0.416b | ||||||||
| (+) | 5 | 3 | 4 | 4 | 5 | 3 | 4 | 4 | ||||
| (−) | 23 | 9 | 20 | 12 | 25 | 7 | 22 | 10 | ||||
| Multifocality | 1.000b | 0.094b | 1.000b | 0.608c | ||||||||
| (+) | 11 | 4 | 6 | 9 | 11 | 4 | 9 | 6 | ||||
| (−) | 17 | 8 | 18 | 7 | 19 | 6 | 17 | 8 | ||||
aLinear by linear association.
bFisher's exact test.
cPearson's Chi-squared test.