Table 1.

Gravimetric characteristics and hemodynamic function of C57BL/6J mice 7 and 28 days after CVB3 infection.

	Control	CVB3, 7 days p.i.	Change	CVB3, 28 days p.i.	Change
Body weight [g]	29 ± 1	22 ± 1∗∗∗	−24%	24 ± 1ns	−17%
LV weight [mg]	124 ± 2	80 ± 1∗∗∗	−35%	80 ± 1∗∗	−35%
Global function
Heart rate [bpm]	585 ± 2	532 ± 8∗∗	−9%	476 ± 12∗∗∗∗	−19%
Cardiac output [mL/min]	15.3 ± 0.9	8.1 ± 0.7∗∗	−47%	6.7 ± 0.6∗∗∗	−56%
Stroke volume [μL]	26.2 ± 1.6	15.2 ± 1.3∗∗	−42%	14.1 ± 1.1∗∗	−46%
Stroke work [μL·mmHg]	2267 ± 172	858 ± 50∗∗∗	−62%	949 ± 118∗∗	−58%
Systolic function
Pes [mmHg]	77 ± 3	44 ± 1∗∗∗∗	−43%	64 ± 6ns	−17%
dP/dtmax [mmHg/s]	9734 ± 407	4080 ± 212∗∗∗∗	−58%	4877 ± 573∗∗	−50%
Ves [μL]	17 ± 1	20 ± 2ns	+16%	15 ± 5ns	−12%
Diastolic function
Ped [mmHg]	4.1 ± 0.3	7.2 ± 0.4∗∗∗	+76%	5.0 ± 0.5ns	+22%
dP/dtmin [mmHg/s]	−6038 ± 256	−2111 ± 254∗∗∗∗	−65%	−3444 ± 486∗	−43%
Tau [ms]	9.2 ± 0.2	15.3 ± 0.7∗∗∗	+65%	14.5 ± 1.4∗∗	+59%
Ved [μL]	42.1 ± 2.1	35.0 ± 1.1ns	−17%	28.8 ± 5.9∗	−32%

Data are presented as mean ± SEM.

^∗Significantly different compared to noninfected mice (control); ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; ^∗∗∗∗P < 0.0001; ^nsnot  significant.

No significances found between CVB3 (7 days) and CVB3 (28 days).