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Specific mechanism of ghrelin involved in the protection of pulmonary artery endothelial cells and activation of the PI3K/AKT/mTOR pathway in human pulmonary artery endothelial cells[44-47]. Solid lines represent activating actions, and dotted lines represent inhibitory actions. PIP2: Phosphatidylinositol 4,5-bisphosphate; PIP3: Phosphatidylinositol 3,4,5-trisphosphate.
