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. 2017 Mar 14;23(10):1816–1827. doi: 10.3748/wjg.v23.i10.1816

Figure 6.

Figure 6

Activation of autophagy protected colorectal cancer cells against oxaliplatin-induced apoptosis by inhibiting miR-34a through the TGF-β/Smad4 pathway. A: HT29 and HT29-oxaliplatin (OXA) cells were transfected with miR-34a mimics and treated with OXA (10 μmol/L) and simultaneously mixed with or without 3-MA. After 48 h, the apoptosis rate was examined by flow cytometry; B: The above cell lysates were examined with the indicated antibodies by western blotting. β-actin was used as loading control. eP < 0.001 indicates a significant difference vs normal control; cP < 0.05 indicates a significant difference vs group treated with OXA.