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. 2017 Mar 14;23(10):1836–1842. doi: 10.3748/wjg.v23.i10.1836

Table 3.

Association between clinicopathological variables and serum HER2 extracellular domain concentrations n (%)

Variables Serum HER2 ECD concentrations
P value
> 24.75 ng/mL (n = 36) ≤ 24.75 ng/mL (n = 203)
Age (yr) 0.474
≥ 60 17 (47.2) 109 (53.7)
< 60 19 (52.8) 94 (46.3)
Gender 0.396
Male 23 (63.9) 144 (70.9)
Female 13 (36.1) 59 (29.1)
Smoking status 0.452
Never 11 (30.6) 50 (24.6)
Ever 25 (69.4) 153 (75.4)
Tumor location 0.573
GEJ 5 (13.9) 36 (17.7)
Non-GEJ 31 (86.1) 167 (82.3)
Tumor size < 0.001
≥ 5 cm 27 (75.0) 75 (36.9)
< 5 cm 9 (25.0) 128 (63.1)
Type of gastrectomy 0.266
Total 21 (58.3) 98 (48.3)
Subtotal 15 (41.7) 105 (51.7)
Type of surgery 0.730
Open 25 (69.4) 135 (66.5)
MIS 11 (30.6) 68 (33.5)
Lymph node involvement 0.419
Positive 22 (61.1) 138 (68.0)
Negative 14 (38.9) 65 (32.0)
pTNM stage 0.576
I 6 (16.7) 33 (16.3)
II 12 (33.3) 66 (32.5)
III 13 (36.1) 89 (43.8)
IV 5 (13.9) 15 (7.4)
Lauren classification 0.021
Intestinal type 22 (61.1) 82 (40.4)
Diffuse type 14 (38.9) 121 (59.6)
Tissue HER2 status (IHC/FISH) < 0.001
Positive 21 (58.3) 18 (8.9)
Negative 15 (41.7) 185 (91.1)

GEJ: Gastroesophageal junction; HER2: Human epidermal growth factor receptor-2; ECD: Extracellular domain; MIS: Minimally invasive surgery; IHC: Immunohistochemistry; FISH: Fluorescence in situ hybridization.