Table 4.

Effects of SLC6A3 SNPs (rs6347, rs3756450, rs2550956 and rs2652510) on risk for PD.

SNPs	Ethnicity (no. of studies included)	Sample size		Allele-wise 2 vs. 1						11 vs. (12 + 22)						22 vs.(12 + 11)
		Case	Control	Odds ratio	95% CI	Significance test		Test for heterogeneity		Odds ratio	95% CI	Significance test		Test for heterogeneity		Odds ratio	95% CI	Significance test		Test for heterogeneity
						z	p	Q	p			z	p	Q	p			z	p	Q	p
rs6347 (1215A/G)	Mixed (8)	4117	7663	0.99	0.93, 1.06	−0.205	0.838	8.497	0.291	1.04	0.96, 1.12	0.868	0.386	10.747	0.15	1.10	0.93, 1.29	1.11	0.267	0.719	0.949
	Caucasian (3)	3333	6737	1.01	0.94, 1.08	0.18	0.857	0.269	0.874	1.02	0.93, 1.11	0.352	0.725	0.452	0.798	1.10	0.93, 1.29	1.117	0.264	0.551	0.759
	Asian (4)	714	826	0.84	0.66, 1.08	−1.376	0.169	6.331	0.097	1.32	0.86, 2.03	1.259	0.208	7.922	0.048	1.47	0.09, 23.68	0.273	0.785	NA	NA
rs3756450 (T/C)	Caucasian (3)	2881	5239	1.02	0.93, 1.13	0.476	0.634	0.879	0.645	0.97	0.87, 1.08	−0.515	0.607	0.299	0.861	0.93	0.41, 2.08	−0.187	0.852	5.589	0.061
rs2652510 (A/G)	Mixed (3)	617	729	1.12	0.83, 1.51	0.721	0.471	6.346	0.042	1.01	0.55, 1.86	0.034	0.973	10.596	0.005	1.32	1.01, 1.73	1.995	0.046	0.764	0.683
	Caucasian (2)	557	663	1.26	1.04, 1.54	2.364	0.018	1.427	0.232	0.74	0.52, 1.05	−1.684	0.092	2.076	0.150	1.37	1.03, 1.84	2.143	0.032	0.153	0.696
rs2550956 (C/T)	Mixed (3)	585	710	0.98	0.69, 1.40	−0.119	0.905	6.222	0.045	1.07	0.78, 1.49	0.426	0.67	3.571	0.168	0.91	0.43, 1.95	−0.234	0.815	4.785	0.091
	Caucasian (2)	525	644	0.84	0.69, 1.01	−1.864	0.062	0.377	0.539	1.20	0.95, 1.52	1.533	0.125	0.001	0.969	0.74	0.44, 1.22	−1.197	0.231	1.384	0.239

The allele before the “/” is predefined as allele 1, and the allele after the “/” is predefined as allele 2.

NA: not applicable.