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. Author manuscript; available in PMC: 2018 Mar 9.
Published in final edited form as: J Med Chem. 2017 Feb 14;60(5):1876–1891. doi: 10.1021/acs.jmedchem.6b01645

Figure 6.

Figure 6

X-ray cocrystal structures of GLP and G9a in complex with 18. (A) Structure of GLP–SAM–18 (green) (PDB 5TTG). (B) Structure of G9a–SAM–18 (blue) (PDB 5TTF). Water molecule is illustrated as a red sphere. Main interactions are shown in yellow dashed lines. (C) Overlay of (A) and (B). (D) Overlay of (A) and GLP–SAH–2 (purple) (PDB 3MO5).