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. Author manuscript; available in PMC: 2018 Mar 9.
Published in final edited form as: J Med Chem. 2017 Feb 14;60(5):1876–1891. doi: 10.1021/acs.jmedchem.6b01645

Scheme 1. Synthesis of 4 and 7–22a.

Scheme 1

aReagents and conditions: (a) 1-alkylpiperidin-4-ylamine, K2CO3, DMF, rt, 80–90%; (b) R′ amines, 4 N HCl in dixoane, i-PrOH, microwave, 160 °C, 75–85%.