Table 2.

Neurosarcoidosis and medical treatment options

Drug name	Initial dose	Side effects	Explanations
Prednisone	1 mg/kg/day, po	Osteoporosis, Cushing syndrome, hypertension, diabetes, peptic ulcus, pseudotumor cerebri, glocom, cataract, euphoria, psychosis
Methylprednisolone	1000 mg/day I.V 3 days	Very rare for 3 days treatment
Methotrexate	10–25 mg once a week po or sc	Anemia, neutropenia, hepatic dysfunction, pneumonia	Should be used combined with folic acid (1 mg day po)
Cyclosporine	5 mg/day should be given in two different doses	Renal failure, hypertension	Expensive
Azathioprine	50 mg, po	Anemia, neutropenia, hepatic dysfunction	Cheap
Cyclophosphamide	50–200 mg po or once in 2–3 weeks 500 mg IV	Cystitis, neutropenia	Urinary function follow up in terms of microscopic hematuria
Hydroxylchloroquine	200 mg/day po	Retinopathy, auto toxicity, myopathy, cardiomyopathy, neuropathy, neurophysiatric effect	Rutine eye examination with 3–6 months intervals
Imfliksimab	3 mg/kg I.V 1.3.5. weeks: then once in each 6 weeks	Fever, headache, dizziness, abdominal pain, dyspepsia, myalgia, arthralgia, polyneuropathy

IV: intravenous; po: per oral