Table 1.

Features of CIS and early multiple sclerosis reported to affect prognosis (4)

Good prognosis	Poor prognosis
Optic neuritis	“Multifocal” CIS
Isolated sensory symptoms	Efferent systems affected
Long interval to second relapse	High relapse rate in the first 2–5 years
No disability after 5 years	Substantial disability after 5 years
Normal MRI	Abnormal MRI with a large lesion load

CIS: clinically isolated syndrome; MRI: magnetic resonance imaging