Table 3.

Clinically isolated syndromes in the differential diagnosis of MS (6)

Type 1 CIS: clinically monofocal, at least one asymptomatic MRI lesion

Type 2 CIS: clinically multifocal, at least one asymptomatic MRI lesion

Type 3 CIS: clinically monofocal, may appear normal; no symptomatic MRI lesion

Type 4 CIS: clinically multifocal, may appear normal; no symptomatic MRI lesion

Type 5 CIS: no clinical presentation to suggest demyelinating disease, but MRI is suggestive

Note: symptomatic lesion should appear typical for demyelination; they may be located in the brain or cord, although they are more often occur in the brain; current evidence on the prognostic value of asymptomatic lesion mainly comes from brain imaging. CIS: clinically isolated syndrome; MS: multiple sclerosis; MRI: magnetic resonance imaging