Table 7.

Magnetic resonance imaging criteria to demonstrate brain abnormality and demonstration of dissemination in space (11)

Original McDonald criteria

2005 revisions

Three of the following: At least one gadolinium enhancing lesion or nine T2 hyperintense lesion if there is no gadolinium-enhancing lesion At least one infratentorial lesion At least one juxtacortical lesion At least three periventricular lesions NOTE: One spinal cord lesion can subsitute for one brain lesion

Three of the following: At least one gadolinium-enhancing lesion or nine T2 hyperintense lesions if there is no gadolinium-enhancing lesion At least one infratentorial lesion At least one juxtacortical lesion At least three periventricular lesions NOTE: A spinal cord lesion can be considered equivalent to a brain infratentorial lesion: an enhancing spinal cord lesion is considered to be equivalent to an enhancing brain lesion, and individual spinal cord lesions can contribute together with individual brain lesions to reach the required number of T2 lesions.