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. 2017 Mar 4;4(1):e000115. doi: 10.1136/bmjgast-2016-000115

Table 4.

Multivariate logistic analysis grouped by type of therapy

Rapid viral response
Lead-in Undetectable or VL ≤15 UI
 
Type of therapy OR 95% CI p Value OR 95% CI p Value
Treatment initiation (Season A vs Season B 43.31 1.88 to 996.65 0.019 3.36 1.10 to 10.16 0.031
HCV RNA (≤600 000 vs >600 000 IU/mL) 23.95 2.75 to 208.41 0.004 8.86 3.02 to 25.94 <0.001
IL-28 polymorphism (CC vs no CC) 7.29 0.94 to 56.17 0.056 4.00 1.34 to 11.94 0.013
Naïve vs experienced 5.68 0.591 to 54.56 0.132 1.02 0.37 to 2.86 0.959
Genotype (1b vs 1a) 0.18 0.02 to 1.62 0.128 0.55 0.17 to 1.799 0.328
Diabetes mellitus (no vs yes) 0.27 0.02 to 3.62 0.326 0.98 0.19 to 0.87 0.985
Age (≥50 vs <50 years) 2.78 0.44 to 17.65 0.276 1.38 0.48 to 3.97 0.542
Fibrosis (≥F3 vs <F3) 3.69 0.22 to 62.58 0.365 0.98 0.17 to 5.63 0.987
Rapid viral response
Without lead-in Undetectable or VL ≤15 UI
Type of therapy OR 95% CI p Value OR 95% CI p Value
Treatment initiation (Season A vs Season B 1.78 1.93 to 2.90 0.021 1.61 0.86 to 3.01 0.131
HCV RNA (≤600 000 vs >600 000 IU/mL) 1.76 1.04 to 3.00 0.035 3.11 1.32 to 7.30 0.009
IL-28 polymorphism (CC vs no CC) 1.81 1.03 to 3.16 0.037 1.84 0.83 to 4.08 0.132
Naïve vs experienced 1.51 0.87 to 2.63 0.138 0.66 0.32 to 1.36 0.267
Genotype (1b vs 1a) 1.52 0.81 to 2.84 0.191 0.74 0.33 to 1.64 0.468
Diabetes mellitus (no vs yes) 1.36 0.64 to 2.85 0.416 1.57 0.67 to 3.67 0.296
Age (≥50 vs <50 years) 0.83 0.49 to 1.40 0.488 0.87 0.44 to 1.69 0.684
Fibrosis (≥F3 vs <F3) 0.88 0.48 to 1.60 0.681 1.89 0.82 to 4.38 0.133