Table 1.
Baseline characteristics of women and men with newly diagnosed atrial fibrillation: the GARFIELD-AF registry
| Variable* | Men (n=15 915) | Women (n=12 709) |
|---|---|---|
| Age, mean (SD), years | 67.6±11.7 | 72.4±10.4 |
| Age group (years), n (%) | ||
| <65 years | 5847 (36.7) | 2670 (21.0) |
| 65–74 years | 5235 (32.9) | 4082 (32.1) |
| ≥75 years | 4832 (30.4) | 5957 (46.9) |
| Race, n %† | ||
| Caucasian/Hispanic/Latino | 10 994 (69.1) | 9240 (72.7) |
| Asian | 4228 (26.6) | 2928 (23.0) |
| Body mass index, mean (SD), kg/m2 | 27.7±5.1 | 27.9±6.2 |
| LVEF category, n (%) | ||
| <40% | 1226 (13.1) | 4378 (6.2) |
| ≥40% | 8098 (86.9) | 6609 (93.8) |
| Type of AF diagnosed, n (%) | ||
| Permanent | 2052 (12.9) | 15 834 (12.5) |
| Persistent | 2585 (16.2) | 1782 (14.0) |
| Paroxysmal | 3988 (25.1) | 3692 (29.1) |
| New (unclassified) | 7289 (45.8) | 5651 (44.5) |
| Medical history, n (%) | ||
| Congestive heart failure, NYHA Class, n (%) | ||
| I | 632 (21.2) | 416 (17.0) |
| II | 1408 (47.3) | 1241 (50.7) |
| III | 792 (26.6) | 682 (27.8) |
| IV | 146 (4.9) | 111 (4.5) |
| Carotid occlusive disease, n (%) | 505 (3.2) | 361 (2.9) |
| PE or DVT, n (%) | 362 (2.3) | 403 (3.2) |
| Systemic embolism | 100 (0.6) | 94 (0.7) |
| Coronary artery bypass graft, n (%) | 689 (4.4) | 164 (1.3) |
| Moderate to severe CKD, n (%) | 1458 (9.2) | 1511 (11.9) |
| Stroke/TIA, n (%) | 1839 (11.6) | 1583 (12.5) |
| Stroke, n (%) | 1243 (7.8) | 1013 (8.0) |
| History of bleeding, n (%) | 469 (3.0) | 311 (2.5) |
| Blood pressure, mm Hg | ||
| Systolic blood pressure, mm Hg, mean (SD) | 132.8 (±19.3) | 135.0 (±20.7) |
| Diastolic blood pressure, mm Hg, mean (SD) | 80.1 (±12.8) | 79.8 (±13.0) |
| Blood pressure ≥140/90 mm Hg, n (%) | 4037 (27.2) | 3741 (31.5) |
| History of hypertension, n (%) | 11 945 (75.2) | 10 212 (80.5) |
| History of hypertension or raised blood pressure ≥140/90 mm Hg, n (%) | 12 634 (79.5) | 10 773 (84.8) |
| Hypercholesterolaemia, n (%) | 6232 (39.9) | 5276 (42.3) |
| Diabetes mellitus, n (%) | 3479 (21.9) | 2728 (21.5) |
| Vascular disease‡, n (%) | 2820 (17.7) | 1508 (11.9) |
| CHA2DS2-VASc score | ||
| Mean (SD) | 2.6 (1.5) | 4.0 (1.4) |
| 0, n (%) | 676 (4.4) | _ |
| 1, n (%) | 2966 (19.1) | 370 (3.0) |
| ≥2, n (%) | 11 857 (76.5) | 12 082 (97.0) |
| Mean HAS-BLED score (SD) | 1.4 (0.9) | 1.5 (0.9) |
| Heavy alcohol consumption, n (%) | 565 (4.2) | 40 (0.4) |
| Current/previous smoker, n (%) | 7210 (50.1%) | 1850 (15.9%) |
*Missing patients from analyses: Number of patients (men, women) with missing values: age (0,0), race (429 346), body mass index (3231, 2858), blood pressure (1051, 830), LVEF (6591, women), type of AF diagnosed (1, 1), congestive heart failure, NYHA class (228, 189), carotid occlusive disease (117, 87), PE or DVT (46, 47), systemic embolism (48, 43), coronary artery bypass graft (350, 208), moderate to severe CKD (2, 1), stroke (33, 30), history of bleeding (37, 38), hypertension (22, 23), hypercholesterolaemia (300, 248), diabetes mellitus (1, 1) vascular disease (1, 1), CHA2DS2-VASc score (416, 257), HAS-BLED score (5230, 3947), alcohol consumption (2516, 1893) smoking habits (1529, 1052).
†346 women and 427 men were unwilling to declare their race or their race was not recorded.
‡Peripheral artery disease or coronary artery disease with a history of acute coronary syndromes.
AF, atrial fibrillation; CKD, chronic kidney disease; CHA2DS2-VASc score, Cardiac failure, Hypertension, Age ≥75 (Doubled), Diabetes, Stroke (Doubled)-Vascular disease, Age 65–74 and Gender category (Female); DVT, deep venous thrombosis; HAS-BLED, Hypertension (uncontrolled, >160 mm Hg systolic), Abnormal renal/liver function, Stroke, Bleeding history or predisposition (anaemia), Elderly (>65) and Drugs/alcohol concomitantly (antiplatelet agents, non-steroidal anti-inflammatory drug); LVEF, left ventricular erection fraction; NYHA, New York Heart Association; PE, Pulmonary embolism; TIA, Transient ischaemic attack.