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. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Cell Metab. 2016 Sep 15;25(1):27–42. doi: 10.1016/j.cmet.2016.08.009

Figure 1. Chemical Transformations of Folates.

Figure 1

Folic acid is reduced to THF, which can then accept a 1C unit and undergo a series of oxidative/reductive transformations. DHF, dihydrofolate; THF, tetrahydrofolate; 5,10-meTHF, 5,10-methylene-THF; 5,10-me+THF, 5,10-methenyl-THF.