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. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Cell Metab. 2016 Sep 15;25(1):27–42. doi: 10.1016/j.cmet.2016.08.009

Figure 2. Products and Compartmentalization of Folate-Mediated 1C Metabolism.

Figure 2

Through an interlinked set of mitochondrial and cytosolic reactions, folate metabolism supports 1C anabolic reactions. All abbreviations are standard gene names. Certain descriptions utilize the common protein name for clarity. SHMT1/2, serine hydroxymethyl transferase, cytosolic(1)/mitochondrial (2); MTHFD1, methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1; MTHFD2/L, methylenetetrahydrofolate dehydrogenase 2/2-like; MTHFD1L, monofunctional tetrahydrofolate synthase, mitochondrial; MTFMT, mitochondrial methionyl-tRNA formyltransferase; TYMS, thymidylate synthetase; MTHFR, methylenetetrahydrofolate reductase; MTR, methionine synthase; DHFR, dihydrofolate reductase; GART, phosphoribosylglycinamide formyltransferase; ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; ALDH1L1/2, cytosolic (1)/mitochondrial (2) 10-formyltetrahydrofolate dehydrogenase.