Table 1.

Other reports of B₁₂ deficiency associated with chromosomal abnormalities

	Reports	N*	Deficiency	Comments
1	Ford, 195916	1	B12	Hypodiploidy; subsequently reported as an error
3	Astaldi et al, 196218	1	B12	Aneuploidy and changes in chromosome morphology Less pronounced after B12 replacement
4	Forteza and Baguena, 196328	1	B12	Aneuploidy
5	Kiossoglou et al, 196519	3	B12	Aneuploidy, chromosomal and chromatid breaks Changes persisted in one after B12 replacement
6	Jensen et al, 196722	4	B12	Increased chromosomal breaks
7	Heath, 196621	14	B12 and folate	Chromosome breakage along with severe megaloblastic changes
8	Bottura et al, 196824	1	B12	Chromosomal breaks in metaphase; corrected after B12 replacement
9	Keller et al, 197020	3	B12	Chromosomal breaks resolved after B12 replacement in one patient
10	Lawler et al, 197123	15	B12 and folate	Chromosomal breaks. Reversal seen in 48 hours with B12 replacement
11	Goh, 198129	1	B12	Del (18p), persisted with replacement. Unlikely from B12 deficiency
12	Wollman et al, 199626	1	B12 and folate	Del (7q) with reversal after B12 replacement
13	Chintagumpala et al, 199625	3	B12	Spontaneous chromosomal fragility. Reversal with B12 replacement in one patient
14	Parmentier et al 201227	1	B12	Del (3p), with reversal of cytogenetic abnormalities after B12 replacement

*N, number of patients described in the case report.

B₁₂, vitamin B₁₂.