Table 1. Correlations between TBL1XR1 expression in tumor tissues and clinical characteristics of stage IV CRCLM patients (Cohort I).
Variables | Cases (n = 47) | TBL1XR1 expression in primary CRC tissues | χ2 test P value | TBL1XR1 expression in liver metastases | χ2 test P value | ||
---|---|---|---|---|---|---|---|
Low (n = 20) | High (n = 27) | Low (n = 13) | High (n = 34) | ||||
Gender | 0.134 | 0.312 | |||||
Female | 20 | 6 | 14 | 4 | 16 | ||
Male | 27 | 14 | 13 | 9 | 18 | ||
Age (year) | 0.886 | 0.248 | |||||
<60 | 17 | 7 | 10 | 3 | 14 | ||
≥60 | 30 | 13 | 17 | 10 | 20 | ||
Primary tumor location | 0.095 | 0.245 | |||||
Colon | 34 | 17 | 17 | 11 | 23 | ||
Rectum | 13 | 3 | 10 | 2 | 11 | ||
Primary tumor differentiation | 0.381 | 0.422 | |||||
Poor | 15 | 5 | 10 | 3 | 12 | ||
Well/Moderate | 32 | 15 | 17 | 10 | 22 | ||
CRCLM distribution | 0.726 | 0.245 | |||||
Unilobar | 34 | 15 | 19 | 11 | 23 | ||
Bilobar | 13 | 5 | 8 | 2 | 11 | ||
No. of CRCLM | 0.020* | 0.768 | |||||
<3 | 34 | 18 | 16 | 9 | 25 | ||
≥3 | 13 | 2 | 11 | 4 | 9 | ||
Resection Margin | 0.270 | 0.495 | |||||
R0 | 39 | 18 | 21 | 10 | 29 | ||
R1 | 8 | 2 | 6 | 3 | 5 | ||
Adjunctive Chemotherapy | 0.366 | 0.159 | |||||
Yes | 37 | 17 | 20 | 12 | 25 | ||
No | 10 | 3 | 7 | 1 | 9 |
Abbreviations: TBL1XR1, Transducin (β)-like 1 X-linked receptor 1; CRC, colorectal cancer; CRCLM, colorectal cancer liver metastases.