Table 2. List of β-hydroxybutyrate-induced genes for each GO term.
Term | Genes (ranked by induction fold) |
---|---|
Signalling transduction | IL-1B*, IL6*, LCN2*, ISG20*, PIK3CD*, TNIP2*, CXCL1, IL11*, WNT5B*, ANKRD1*, EIF2C4* |
Cell growth and proliferation | IL-1B*, SOD2, IL6*, ISG20*, LEPREL2*, GATA2*, CXCL1, IL11* |
Metabolic process | IL-1B*, ADA*, ISG20*, KYNU*, ANKRD1*, TUBB2B |
Apoptosis-related pathway | IL-1B*, OLR1*, SOD2, IL6*, ADA*, LCN2*, TNIP2*, TREX1*, ANKRD1* |
Oxidative stress response | IL-1B*, OLR1*, SOD2, IL6*, ADA*, LCN2* |
Asterisks indicated that genes were highly expressed in breast tumour compared to normal mammary tissue (data were adapted from Oncomine database, https://www.oncomine.org/resource/login.html).