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. 2017 Mar 10;8:14702. doi: 10.1038/ncomms14702

Figure 1. Schematic illustration of the ACIE bioimaging system and fabrication procedure.

Figure 1

(a) Microcarrier fate tracking and drug-release monitoring by the ACIE bioimaging system using an InGaAs CCD camera. After oral administration, the BSA–NPTAT-loaded microcarriers showed little protein drugs leakage in the GI tract (pH=1) but sustained release in the intestine (pH=8) due to the deprotonation of the SSPI on the outer surface of the microcarrier. (b) Procedures of NIR-II fluorescent mesoporous microcarriers preparation, protein drugs loading and SSPI grafting.