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. 2017 Mar 16;10:16. doi: 10.1186/s12920-017-0253-6

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Comparing the expression of genes in the HOXA&B module. Expression of every member of HOXA&B module is shown in one column. Each row corresponds to a sample from the MILE dataset. The majority of HOXA and HOXB genes in this module are not expressed in MDS. Their expression in AML are variable indicating the heterogeneity of the disease. They anticorrelate with GNG2, CD48, and APP, which have the least negative weight (-0.7) in the corresponding eigengene (the green strip at the top). These patterns are similar in the BCCA dataset (Additional file 1: Figure S7)