Fig. 3.

Pyrazole- and phenobarbital-induced expression of liver Cyp2a4/5 mRNAs in mice from different strains. Female mice were treated with phosphate buffered saline (CON, PBS 10 mL/kg body weight/day × 3 days, i.p), pyrazole (PYR, 100 mg/kg body weight/day × 3 days, i.p.) or phenobarbital (PB, 80 mg/kg body weight/day × 3 days, i.p.). Relative quantification of mRNA was made by qPCR taking the control mice (CON) as the reference. An asterisk (*) above the bar indicates that mRNA levels differ (P < 0.05, Kruskal–Wallis test followed by Mann–Whitney U test with Bonferroni’s correction) from those of vehicle-controls (CON) of the same strain. N = 6 mice of each strain per treatment group