Fig. 4.

Interstrain differences in serum levels of ALT after treatment with pyrazole or phenobarbital. ALT serum levels (IU/L) in BALB/c, CBA, B6, B10, D1, D2, F1 and SW mice treated with phosphate buffered saline (CON, PBS 10 mL/kg body weight/day × 3 days, i.p), pyrazole- (PYR, 100 mg/kg body weight/day × 3 days, i.p.) or phenobarbital (PB, 80 mg/kg body weight/day × 3 days, i.p.). ALT serum levels are expressed as ratio of PYR- or PB-treated to average control group levels (100%). * levels are different from those of vehicle controls (CON) of the same strain (P < 0.05, Kruskal–Wallis test followed by Mann–Whitney U test with Bonferroni’s correction). N = 6 mice of each strain per treatment group