Table 1.

Liver Cyp2a5 (COH), Cyp1a1/2 (EROD) and Cyp2b9/10 (BROD) activities in different mouse strains. Female mice were treated ip with PBS (CON), pyrazole (PYR 100 mg/kg bw/days × 3 days), or phenobarbital (PB, 80 mg/kg bw/days × 3 days) and euthanized 24-h after the last dose

Treatment	Monooxygenase activity (pmoles/mg protein/min)
	COH			EROD			BROD
	CON	PYR	PB	CON	PYR	PB	CON	PYR	PB
Mouse strain
BALB/cAn	35.2 ± 2.9	69.7 ± 4.4*	75.3 ± 6.0*	71.2 ± 6.0	103.1 ± 9.0	532.7 ± 77.5*	56.6 ± 5.7	53.3 ± 4.0	192.8 ± 23.9*
CBA	32.9 ± 5.0	119.7 ± 5.2*	91.9 ± 5.4*	74.9 ± 4.9	61.5 ± 5.5	293.0 ± 33.7*	22.0 ± 2.3	19.8 ± 3.5	212.5 ± 22.4*
C57BL/6	44.5 ± 6.0	112.1 ± 8.4*	62.2 ± 5.5	99.2 ± 7.2	98.7 ± 8.6	444.3 ± 28.6*	47.3 ± 5.8	33.4 ± 4.8	158.9 ± 8.7*
C57BL/10	24.4 ± 3.8	88.1 ± 4.1*	63.6 ± 5.9*	132.2 ± 9.4	135.5 ± 16.9	598.7 ± 59.5*	42.6 ± 3.5	72.9 ± 29.9	181.3 ± 5.5*
DBA-1	142.5 ± 28.3	344.8 ± 50.6*	261.8 ± 24.6	50.2 ± 3.3	50.0 ± 4.0	265.7 ± 13.1*	26.8 ± 1.4	43.4 ± 12.4	271.0 ± 2.3*
DBA-2	228.4 ± 24.8	507.7 ± 12.5*	493.5 ± 11.7*	74.9 ± 7.9	64.3 ± 6.3	338.1 ± 14.8*	39.8 ± 2.8	41.0 ± 3.8	266.9 ± 28.5*
B6D2F1	113.3 ± 11.6	437.8 ± 24.3*	308.4 ± 20.6*	68.8 ± 3.4	66.6 ± 3.6	251.1 ± 14.1*	35.2 ± 4.1	45.0 ± 5.3	306.5 ± 8.8*
SW	24.1 ± 5.3	78.5 ± 8.8*	42.5 ± 3.1	72.8 ± 7.6	74.8 ± 9.1	348.5 ± 29.7*	41.2 ± 7.8	38.8 ± 10.2	143.6 ± 4.4*

Values are shown as mean ± SEM. Data were evaluated by ANOVA and Dunnett’s post hoc test. Means that are different (P < 0.05) from respective controls are indicated by an asterisk (*). N = 6 mice of each strain per group (CON, PYR or PB)

COH (coumarin 7-hydroxylase) pmoles umbelliferone/mg protein/min, EROD (ethoxyresorufin-), BROD (benzyloxy-resorufin-O-dealkylase) pmoles resorufin/mg protein/min