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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Clin Psychol Sci. 2016 Oct 19;5(1):158–165. doi: 10.1177/2167702616651075

Table 1.

Additive genetic effects on HRSD and QIDS phenotypes.

Variable Unrelated subsample
Full sample
Using all SNPs
Using Gene Sets
Using all SNPs
Using Gene Sets
h2SNP h2SNP-Monoamine h2SNP-All Others h2 SNP h2SNP-Monoamine h2SNP-All Others
HRSD measures
No Covariates
Severity at enrollment (N=1359) 1 0.49 [0.12, 0.87]*** 0.00 [−0.04, 0.04] 0.49 [0.11, 0.86]** 0.52 [0.24, 0.81]*** 0.01 [−0.02, 0.04] 0.52 [0.24, 0.81]***
Change in severity (N=1174) 1 0.47 [−0.02, 0.95]* 0.00 [−0.04, 0.04] 0.43 [−0.05, 0.91]a 0.58 [0.21, 0.94]*** 0.03 [−0.01, 0.07]a 0.58 [0.22, 0.95]***
Remission (N=1359) 1 0.33 [−0.16, 0.82] 0.01 [−0.03, 0.05] 0.28 [−0.20, 0.75] 0.40 [0.04, 0.75]** 0.04 [−0.01, 0.08]* 0.38 [0.03, 0.73]**
Age, sex, weeks in treatment and 2APCs/3APCs as covariates
Severity at enrollment (N=1358) 2 0.35 [−0.07, 0.76]* 0.00 [−0.04, 0.04] 0.35 [−0.06, 0.75]* 0.48 [0.19, 0.77]*** 0.00 [−0.03, 0.03] 0.48 [0.19, 0.77]***
Change in severity (N=1173) 2 0.37 [−0.12, 0.86]a 0.00 [−0.04, 0.04] 0.35 [−0.13, 0.83]a 0.30 [−0.09, 0.70] 0.00 [−0.04, 0.04] 0.31 [−0.09, 0.70]
Remission (N=1358) 2 0.29 [−0.20, 0.79] 0.00 [−0.04, 0.05] 0.26 [−0.22, 0.74] 0.23 [−0.15, 0.61] 0.02 [−0.02, 0.07] 0.22 [−0.16, 0.60]
QIDS-C measures
No Covariates
Severity at enrollment (N=1359) 1 0.24 [−0.12, 0.60]a 0.00 [−0.04, 0.04] 0.23 [−0.11, 0.58]a 0.19 [−0.08, 0.46]* 0.02 [−0.02, 0.05] 0.19 [−0.08, 0.46]*
Change in severity (N=1174) 1 0.52 [0.10, 0.95]* 0.00 [−0.03, 0.03] 0.52 [0.10, 0.94]* 0.59 [0.27, 0.91]*** 0.03 [−0.01, 0.06]* 0.58 [0.27, 0.90]***
Remission (N=1359) 1 0.56 [0.13, 0.98]** 0.00 [−0.03, 0.03] 0.55 [0.13, 0.98]** 0.57 [0.26, 0.88]*** 0.03 [−0.01, 0.06]* 0.57 [0.26, 0.88]***
Age, sex, weeks in treatment and 2APCs/3APCs as covariates
Severity at enrollment (N=1358) 2 0.12 [−0.29, 0.53] 0.00 [−0.04, 0.04] 0.11 [−0.28, 0.51] 0.21 [−0.10, 0.51] 0.00 [−0.03, 0.03] 0.21 [−0.10, 0.51]
Change in severity (N=1173) 2 0.48 [0.05, 0.90]* 0.00 [−0.03, 0.04] 0.48 [0.06, 0.91]* 0.41 [0.08, 0.75]* 0.01 [−0.02, 0.05] 0.41 [0.07, 0.74]*
Remission (N=1358) 2 0.64 [0.21, 1.06]** 0.00 [−0.04, 0.04] 0.64 [0.22, 1.07]** 0.49 [0.16, 0.82]** 0.01 [−0.02, 0.04] 0.49 [0.16, 0.81]**

Notations:

a

= p-value (p) < 0.10,

*

= p < 0.05,

**

= p < 0.01,

***

= p < 0.001,

1

= actual sample size for analyses without covariates using the full sample was N=1615, except for “Change in severity” which had an N of 1371.

2

= actual sample size for analyses with covariates using the full sample was N=1610, except for the “change in severity” variable that had N=1366. Note that for the unrelated sample the first two ancestral principle components (APCs) are used to control for population stratification while the first three APCs are used in the analysis of full sample.