Table 3.
Impact of neoadjuvant chemotherapy on healthy tissue (PP)
| Metabolite | Neoadjuvant chemotherapy | Mean (nmol/mg) | p value |
|---|---|---|---|
| Ascorbate | No | 0.3488 ± 0.2191 | 0.6730 |
| Yes | 0.3592 ± 0.1671 | ||
| Aspartic acid | No | 0.7577 ± 0.3284 | 0.9626 |
| Yes | 0.6730 ± 0.1776 | ||
| Choline | No | 1.5580 ± 0.5921 | 0.7430 |
| Yes | 1.7649 ± 0.7624 | ||
| Creatine | No | 1.7371 ± 0.9568 | 0.5414 |
| Yes | 1.7760 ± 0.6579 | ||
| Ethanolamine | No | 0.9314 ± 0.4502 | 0.6058 |
| Yes | 1.1115 ± 0.5408 | ||
| Glutamate | No | 2.9830 ± 0.8698 | 0.8148 |
| Yes | 2.3800 ± 0.4264 | ||
| Glycerol | No | 8.1840 ± 7.3988 | 0.6730 |
| Yes | 8.2990 ± 7.2904 | ||
| Glycine | No | 6.0920 ± 5.0908 | 0.5414 |
| Yes | 6.5590 ± 5.7401 | ||
| Glycerophosphocholine | No | 2.4215 ± 2.6084 | 0.9626 |
| Yes | 2.2208 ± 2.1689 | ||
| Lactate | No | 11.0040 ± 2.4733 | 0.3704 |
| Yes | 9.6770 ± 2.1588 | ||
| Phosphorylcholine | No | 1.1690 ± 0.6396 | 0.8148 |
| Yes | 0.9469 ± 0.3644 | ||
| Taurine | No | 2.9660 ± 1.9594 | 0.9626 |
| Yes | 2.7060 ± 1.3103 | ||
| Threonine | No | 1.1202 ± 0.2821 | 0.6730 |
| Yes | 1.1678 ± 0.2801 | ||
| Glutamine | No | 0.6855 ± 0.2518 | 0.5414 |
| Yes | 0.5633 ± 0.1466 | ||
| Succinic acid | No | 0.3069 ± 0.2121 | 0.8884 |
| Yes | 0.2595 ± 0.1406 | ||
| Glucose | No | 1.2247 ± 0.6158 | 0.4807 |
| Yes | 1.0736 ± 0.7355 | ||
| Tyrosine | No | 0.0520 ± 0.0442 | 0.6058 |
| Yes | 0.0552 ± 0.0599 | ||
| Phenylalanine | No | 0.1449 ± 0.0771 | 0.8148 |
| Yes | 0.1495 ± 0.0880 |
Results of the Mann-Whitney U test. Metabolite differences between PP without neoadjuvant chemotherapy and PP with neoadjuvant chemotherapy (univariate analysis, nonparametric test)