Figure 4.

Immune-dependent growth kinetics of PyMT cell lines. PyMT cell lines were generated from primary tumors from PyMT mice (A) Rag1^−/− or (B) WT mice. Each cell line was subsequently passaged in either severely immune deficient Rag2^−/− x γc^−/− (open circle) or WT mice (closed square). For each cell line, a dotted line shows the age at which tumor size reached a 10×10 mm mean tumor diameter. (C) The primary tumor latency of each cell lines was reported on the graph showing the primary tumor onset of PyMT/Rag1^−/− mice vs. PyMT WT mice.