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. 2016 Dec 7;6(2):e1265717. doi: 10.1080/2162402X.2016.1265717

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Figure 1. — Human data provides the rationale for construction of Ad3-hTERT-CMV-hCD40L. (A) A breast cancer patient was treated with Ad3-hTERT-E1A (CGTG-201) virus intravenously (I.V). Presence of virus in tumor biopsies was measured with qPCR 6 d later. (B) Immunomodulatory effects of hCD40L coding adenovirus on intratumoral DCs in cancer patients. Gene expression of DC maturation and differentiation markers were analyzed from tumor biopsies of patients treated with hCD40L and GMCSF coding adenoviruses.