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. 2017 Mar 16;7:44265. doi: 10.1038/srep44265

Figure 1. Increased VSOR Cl− currents in high glucose-exposed cardiomyocytes.

Figure 1

(A) Negligible background Cl− currents were recorded under isosmotic solution (Ctrl). High glucose (HG, 40mM)-induced Cl− currents exhibit representative properties of VSOR Cl− currents, which were inhibited by adding DIDS (500 μM); n = 5 for each group. (B) Corresponding current-voltage (I–V) relationship for the mean current densities of cells subjected to indicated treatments. (C) Current densities at +100 mV from. (B) *P < 0.05 v.s. Ctrl; **P < 0.05 v.s. HG, n = 5. (D) Cl− currents recorded under isosmotic solution (Ctrl), HG alone or HG and DCPIB (10 μM) treatment. n = 5 for each group. (E) Corresponding current-voltage (I–V) relationship for the mean current densities of cells subjected to indicated treatments. (F) Current densities at +100 mV from (E). *P < 0.05 v.s. Ctrl; **P < 0.05 v.s. HG, n = 5.