Table 1. Histopathological analysis of met mutant mice.
| Tumor/lesion | M1248Tmu/+ | Y1228Cmu/+ | M1248T/L1193Vmu/+ | D1226Nmu/+ | WTmu/+ |
|---|---|---|---|---|---|
| Sarcomas | |||||
| Hemangiosarcoma | — | 10 | 4* | 13 | — |
| Fibrosarcoma | — | 1 | 1* | 2* | — |
| Myxoma | — | 1† | — | — | — |
| Leiomyosarcoma | — | — | 1 | — | — |
| Spindle-like | — | — | 1 | — | — |
| Lymphomas | |||||
| Histiocytic sarcoma | 5 | 5 | 1 | — | 1 |
| Lymphoblastic | — | — | 1 | — | 2 |
| Lymphocytic | 1 | 1 | — | — | — |
| Follicular center | 1 | — | — | — | — |
| Carcinomas | |||||
| Transitional cell | 1 | — | — | — | — |
| Squamous cell | 1 | — | — | — | — |
| Lung adenocarcinoma | 1 | — | — | — | 1 |
| Lung adenoma | 1 | — | — | — | 1 |
| Basosquamous adenocarcinoma | 1 | — | — | — | — |
| Hepatoma | 1 | — | 1 | — | — |
| Nonremarkable | 1 | 0 | 3 | 3 | 4 |
Some mice contained more than one tumor. Some mice also had pathological phenotypes that were not reported in this study; therefore, these mice were not included in the “nonremarkable pathology” group. Lung adenomas and hepatomas may have been observed due to the old age of the mice.
*
Tumors in which metastatic lesions were observed.
†
The myxoma was contiguous with a hemangiosarcoma (shown in Fig. 3D).