Table 4.

Frequency of adverse events noted over the course of treatment with darbepoetin

Adverse event	Number of dogs monitored	Adverse event occurred during darbepoetin treatment	Intervention for adverse event deemed warranted	Darbepoetin discontinued
Increase in systolic blood pressure	25	24	13	0
Hyperkalemia (>5.2 mmol/L)	33	14	0	0
Thrombocytosis (>530,000/μL)	23	4	0	0
Polycythemia (packed cell volume >60%)	33	0	0	0
Seizures	33	5	2	0
Diarrhea	33	3	0	0
Vomiting	33	3	0	0
Cutaneous reaction	33	0	0	0
Hypersensitivity reaction to darbepoetin	33	0	0	0
Hypersensitivity reaction to iron dextran	33	1	1	0
Pure red cell aplasia suspected	33	2	2	2