Figure 8.
By fluorescence in situ hybridization, 13 SMARCB1-deficient sinonasal carcinomas demonstrated homozygous deletion of SMARCB1, with both SMARCB1 alleles deleted (red), while 2 copies of EWSR1 (green) are present. See in contrast normal cells having 2 copies of both green and red signals (top right) (A). Six SMARCB1-deficient sinonasal carcinomas exhibited heterozygous SMARCB1 deletion, with only one copy of SMARCB1 present (red) while 2 copies of EWSR1 (green) are seen.