Table 2.
Immunohistochemical findings in sinonasal SMARCB1-deficient carcinoma (n=39).
| No | Pan-CK | CK7 | p63 | CK5 | CHgA | SYN | CD56 | CD117 | p16 | NUT | EBV ISH | HPV PCR or ISH | SMARCB1 | SMARCA2 | SMARCA4 | ARID1A | SMARCB1 FISH |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | + | − | − | + | − | − | − | − | + | − | − | − | Lost | Reduced | Reduced | Intact | Biallelic deletion, monosomy 22q |
| 2 | + | − | − | + | − | + | + | − | +F | − | − | − | Lost | Reduced | Intact | Intact | Biallelic deletion |
| 3 | + | − | + | + | − | − | − | − | + | − | − | − | Lost | Reduced | Intact | Intact | Monoallelic deletion + monosomy 22q |
| 4 | + | − | − | + | − | − | − | − | − | − | − | − | Lost | Reduced | intact | Intact | Intact |
| 5 | + | − | − | − | − | − | − | − | − | − | − | − | Lost | Reduced | Intact | Intact | Intact |
| 6 | + | − | + | F+ | − | − | − | − | − | − | − | − | Lost | Reduced | Intact | Intact | Biallelic deletion |
| 7 | + | − | + | F+ | − | − | ++ | − | − | − | − | − | Lost | Reduced | Intact | Intact | Monoallelic deletion |
| 8 | + | − | − | + | ND | − | ND | − | ND | − | ND | − | Lost | Reduced | NR | Intact | NR |
| 9 | + | + | − | − | ND | ND | ND | − | ND | − | ND | ND | Lost | NR | NR | Intact | NR |
| 10 | + | ND | F+ | F+ | ND | − | ND | − | ND | − | ND | ND | Lost | Reduced | NR | Intact | NR |
| 11 | + | + | − | F+ | − | − | ND | − | − | − | ND | ND | Lost | Reduced | Intact | Intact | NR |
| 12 | + | − | − | − | − | − | +F | − | − | − | − | ND | Lost | Reduced | Intact | Intact | Intact |
| 13 | + | F+ | F+ | + | − | F+ | + | − | − | − | ND | − | Lost | Reduced | Intact | Intact | Biallelic deletion |
| 14 | + | − | + | + | − | F+ | − | − | + | − | ND | − | Lost | Reduced | Intact | Intact | Biallelic deletion |
| 15 | + | + | − | − | − | − | − | − | + | − | ND | − | Lost | ND | Intact | Reduced | NR |
| 16 | + | F+ | + | + | − | − | ND | − | − | − | ND | − | Lost | Lost | Mosaic | Intact | Biallelic deletion |
| 17 | + | − | − | − | − | − | − | − | − | − | ND | − | Lost | Reduced | Intact | Intact | Monosomy 22q |
| 18 | + | − | − | − | − | − | ND | − | − | − | ND | − | Lost | Reduced | NR | Intact | NR |
| 19 | + | + | − | − | − | − | − | − | − | − | ND | − | Lost | Intact | Intact | Intact | Intact |
| 20 | + | − | + | F+ | − | − | − | − | − | − | ND | − | Lost | Lost | Intact | Intact | Monoallelic deletion + partial monosomy 22q |
| 21 | + | − | + | F+ | − | − | − | − | ND | − | Lost | Reduced | Intact | Intact | Biallelic deletion | ||
| 22 | + | F+ | + | + | − | − | − | − | − | ND | − | Lost | Reduced | Intact | Intact | Biallelic deletion | |
| 23 | + | + | ND | ND | − | + | + | − | − | ND | Lost | Intact | Intact | Intact | Monosomy 22q | ||
| 24 | + | F+ | + | F+ | F+ | − | F+ | + | − | − | − | − | Lost | Lost | Intact | Intact | Biallelic deletion + monosomy 22q |
| 25 | + | − | F+ | ND | − | − | ND | − | − | − | ND | − | Lost | Lost | Intact | Intact | NR |
| 26 | + | + | + | F+ | F+ | F+ | − | − | − | − | − | Lost | Intact | Intact | Intact | Monosomy 22q | |
| 27 | + | F+ | − | − | − | − | − | + | − | − | ND | − | Lost | Intact | Intact | NR | Equivocal, partial Monosomy 22q |
| 28 | − | − | − | − | − | − | − | ND | − | − | − | − | Lost | Reduced | Intact | ND | Biallelic deletion |
| 29 | + | F+ | F+ | ND | − | − | ND | ND | ND | ND | ND | ND | Lost | Reduced | Intact | ND | ND |
| 30 | + | ND | + | F+ | F+ | ND | ND | + | ND | ND | ND | ND | Lost | ND | ND | ND | Biallelic deletion |
| 31 | + | F+ | F+ | − | − | ND | ND | − | − | − | − | − | Lots | ND | ND | ND | Biallelic deletion |
| 32 | + | ND | ND | − | − | ND | ND | ND | − | ND | ND | ND | Lots | ND | ND | ND | Biallelic deletion |
| 33 | + | F+ | F+ | F+ | − | F+ | F+ | − | − | − | − | − | Lost | Intact | Intact | ND | Failed |
| 34 | + | ND | − | ND | − | − | ND | ND | − | ND | ND | ND | Lost | ND | ND | ND | NR |
| 35 | + | + | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | Lost | ND | ND | ND | Intact |
| 36 | + | ND | F+ | ND | ND | − | − | ND | − | ND | − | ND | Lost | ND | ND | ND | Monosomy |
| 37 | + | ND | + | ND | − | − | − | ND | − | ND | − | − | Lost | ND | ND | ND | Biallelic deletion |
| 38 | + | ND | + | + | − | − | − | ND | − | ND | ND | ND | Lost | ND | ND | ND | ND |
| 39 | + | ND | − | ND | ND | ND | ND | ND | ND | ND | ND | ND | Lost | ND | ND | ND | Intact |
CK=cytokeratin; CHgA=chromogranin A; SYN=synaptophysin; EBV= Epstein-Barr virus; ISH=in situ hybridization; HFV=human papillomavirus; F= focal; ND= not done; NR=not reported