Figure 5. Concentrations of MMP-2 and MMP-3 in culture supernatants with dexamethasone (dexa). Addition of dexamethasone decreased periostatin-mediated MMP-2 and MMP-3 production levels in cultured synovial cells. (A) Effect of the dexamethasone on spontaneous productivity of MMP-2. (B) Effect of the dexamethasone on spontaneous productivity of MMP-3. (C) Suppression efficacy of dexamethasone for periostin’s MMP-2 production on synovial cells. (D) Suppression efficacy of dexamethasone for periostin’s MMP-3 production on synovial cells. Asterisks indicate significant differences (**p<0.01). Error bars denote±standard deviation.
