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. 2017 Mar 16;12(3):e0169687. doi: 10.1371/journal.pone.0169687

Fig 7. Proposed model for FBLIM1’s involvement in CRMO.

Fig 7

FBLIM1 expression is regulated by STAT3 and NR4A2 binding. FBLP1 blocks the phosphorylation of ERK1/2; in its absence or when dysfunctional, the increased phosphorylation of ERK1/2 leads to increased RANKL production, subsequent osteoclast activation, and bone resorption, as well as inflammasome activation. Mutations like rs41310367 disrupt regulation and expression of FBLIM1, resulting in decreased osteoblast activity and subsequent bone loss.