Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 12;36(21):3002–3014. doi: 10.1038/onc.2016.454

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

NOX4 suppresses the actomyosin regulators RhoA/C and Cdc42. (a and c) RhoA, RhoC and Cdc42 GTPases mRNA expression levels analysed by quantitative PCR. Data represents the mean±s.e.m. (N=4). (b and d) Representative western blot of RhoA, RhoC and Cdc42 GTPases. GAPDH was used as loading controls (N=3–5). Quantification normalized by loading control is shown under each blot. (e) Scatter plots of NOX4, RhoC, Cdc42 and MYL9 (MLC2) expression correlation analysis using normalized mRNA expression data from GEO data sets (accession number GSE40367). (f) NOX4, RhoC, Cdc42 and MYL9 (MLC2) expression levels comparing primary tumour versus metastasis using same data set as in e. (g) Kaplan–Meier estimates of 5 years survival in The Cancer Genome Atlas HCC patients according to NOX4 expression combined with RhoC and Cdc42 expression.