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NOX4 suppresses amoeboid invasion in HCC. (a) NOX4 maintains epithelial parenchymal structures in non-invasive HCC. Loss of NOX4 promotes disruption of cell–cell and cell–substrate adhesion and increased RhoC and Cdc42 GTPases expression, favouring amoeboid invasion. (b) HCC aggressiveness is promoted through epithelial to amoeboid transition upon NOX4 loss.
