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. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551

Fig 5. Dose-dependent suppression of OD1-induced spontaneous pain by m3-HwTx-IV.

Fig 5

(A) Effect of co-administration of m3-HwTx-IV (i.pl.; 100 nM, 300 nM) on the time course of spontaneous pain behaviours elicited by intraplantar injection of the NaV1.7 activator OD1 in mice. (B) Effect of m3-HwTx-IV (i.pl; 100 nM, 300 nM) on total pain behaviours (0–40 min) induced by OD1 in mice. Data are presented as mean ± SEM, n = 3–5 mice per group. Statistical significance was determined using one-way ANOVA with Dunnett’s post-test, *P < 0.05 compared to control.