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Schematic illustration of ARPP-16 regulation in striatal neurons. ARPP-16 is phosphorylated by MAST3 at Ser46 to a high basal stoichiometry in striatum, which leads to selective inhibition of PP2A activity. Dephosphorylation of Ser46 in ARPP-16 is increased by activation of PKA or by stimulation of NMDA receptors, leading to disinhibition of PP2A.
