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. 2017 Mar 15;37(11):2947–2959. doi: 10.1523/JNEUROSCI.3499-16.2017

Figure 1.

Figure 1.

Effects of BF-ES in vivo on CHT-mediated, HC-3-dependent choline transport (n = 20; n = 5 GTs and 5 STs for BF-ES; n = 5 GTs and 5 STs for sham stimulation). After 20 min of BF-ES, cortical and striatal tissues were harvested and synaptosomes were prepared for measuring choline uptake. a, c, Saturation curves for choline uptake by synaptosomes from frontal cortical and striatal tissues. b, d, Vmax values for cortical and striatal synaptosomes. In GTs, BF-ES significantly increased the capacity of cortical CHTs to transport choline (b). No such effect was found in STs. Striatal Vmax values were unaffected by phenotype or BF-ES. BF-ES may have spread into the striatum to yield an insignificant increase in striatal synaptosomes from GTs (d). Km values were not affected by phenotype or BF-ES in either region (see Results for ANOVAs; multiple comparisons for this and subsequent figures: *p < 0.05; **p < 0.01; ***p < 0.001).