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. 2017 Mar 1;37(9):2279–2291. doi: 10.1523/JNEUROSCI.2193-16.2016

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Copyright © 2017 Brooks, Davies et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Whole-brain mixed-effects analysis of the main effect of temperature. Activity in response to high > low temperature stimuli revealed a widespread network of cortical and subcortical regions, as has been previously demonstrated in response to painful thermal stimulation (Apkarian et al., 2005). In particular, contralateral activity was observed in the dorsal posterior insula (dpIns), S1, S2, and thalamus (Thal). Further regions activated include the rostral anterior cingulate cortex (rACC), frontal pole (FP), and Crus I in the cerebellum. A negative main effect of temperature (low > high) was observed in a region overlapping frontal medial cortex (FMC)/paracingulate gyrus (PCG). Data were obtained from cluster-based thresholding using an initial threshold of Z > 3.09 and corrected significance level of p < 0.05.