Fig 4. Gα₁₁KO/Gα_q-eKO mice have delayed wound healing.

Gα₁₁KO/Gα_q-WT control and Gα₁₁KO/Gα_q-eKO mice received 15 mm incisional wound and closure was monitored over 18 days. A) Gross examination of the wounds in Gα₁₁KO/Gα_q-WT control (N = 15) and Gα₁₁KO/Gα_q-eKO (N = 10) mice. B) Initial wound size. Statistical significance determined by Student’s t-test. C) Kaplan-Meier survival curve of wound closure. Statistical significance was determined by log-rank test. D) Wound closure over time. Statistical significance was determined by two-way ANOVA. E) Wound half-life for Gα₁₁KO/Gα_q-WT control and Gα₁₁KO/Gα_q-eKO animals, as determined from the rate of wound closure over time. Statistical significance was determined by Student’s t-test, ***p<0.001.