Table 1. Main characteristics of transient H3K9me2 blocks (dLOCKs) with strongest variations among myeloid cells.

dLOCK category	alpha	% of the genome	average dLOCK size, bp	number of genes	number of dLOCKs	gene density/ genome average	enriched genomic features (alpha > 0.99; alpha <0.01)	fold enrichment
CD34+ >Granulocyte
							35. Histone H3K27me3	2.6
	>0.99	3.21%	487549	724	204	1.1	47. cancer SNV AML	2.46
	>0.95	9.48%	287959	2742	1019	1.04	3. Poised Promoter	2.17
	>0.90	13.97%	212223	4760	2038	1.01	37. histone H3K9me1	1.72
							8. Insulator	1.59
Granulocyte > CD34+
							15. Repetitive CNV	1.76
	< 0.01	5.54%	695121	1063	248	0.76	47. cancer SNV AML	1.72
	< 0.05	15.17%	381246	2523	1236	0.74	38. histone H3K9me3 Peaks	1.7
	< 0.10	20.96%	263351	3568	2471	0.73	14. Repetitive CNV	1.56
	CD34+ > AML							15. Repetitive CNV	2.67
							12. Repressed Chromatin	2.14
							42. HAIBMethylRRBS sites Rep2	1.95
>0.99		4.35%	698394	1278	193	0.87	41. HAIBMethylRRBS sites Rep1	1.94
>0.95		12.20%	393652	3610	961	0.83	35. Histone H3K27me3	1.87
>0.90		17.46%	281713	5264	1921	0.84	47. cancer SNV AML	1.8
							14. Repetitive CNV	1.79
							43. CpG Islands	1.6
							3. Poised Promoter	1.5
AML > CD34+
	< 0.01	3.91%	446827	545	271	1	47. cancer SNV AML	1.92
	< 0.05	11.72%	268043	2030	1354	1.03	44. vistaEnhancers	1.86
	< 0.10	17.52%	200314	3400	2707	1	50. AML chromosome translocations	1.72
	Granulocyte > AML
>0.99		5.77%	931140	1362	193	0.81	15. Repetitive CNV	2.62
>0.95		15.31%	493223	3057	965	0.71	47. cancer SNV AML	1.67
>0.90	21.01%	338224	4133	1931	0.71	14. Repetitive CNV	1.66
AML > Granulocyte							12. Repressed Chromatin	2.64
							35. Histone H3K27me3	2.31
	< 0.01	3.84%	484980	746	245	1.23	47. cancer SNV AML	1.78
	< 0.05	11.20%	281623	2953	1232	1.17	37. histone H3K9me1	1.74
	< 0.10	16.81%	211270	4959	2465	1.13	3. Poised Promoter	1.69
							7. WeakEnhancer	1.6
							19. DNase Clustered	1.53

Chromosomal domains with strongest changes in H3K9me2 Sum Log Ratio were determined for the six comparative categories of H3K9me2 dLOCKs: high in CD34+ vs. granulocyte (CD34+ > Granulocyte); high in granulocytes vs. CD34+ (Granulocyte > CD34+); high in CD34+ vs. AML cluster A (CD34+ > AML); high in AML cluster A vs. CD34+ (AML > CD34+); and high in granulocytes vs. AML A (CD34+ > AML); high in AML cluster A vs. granulocytes (AML > Granulocytes). Percent of the human genome, average LOCK size, total number of genes in dLOCKs, total number of dLOCKs, and average genes/dLOCKs are shown for each category with alpha > 0.90, 0.95, 0.99 and alpha < 0.10, 0.05, 0.01. Selected genomic features enriched more than 1.5 fold are shown for each category with alpha > 0.99 and alpha < 0.01. For genomic references (as numbered) and other enrichment data see Materials and Methods and S6 Table.