Table 3. Effect of each of the four BH sonication parameters on significant increase in lesion volume and focal region temperature are summarized.

Increasing acoustic power did not result in an increase in lesion volume, whereas temperature distribution and area of lethal thermal dose increased. While increasing number of cycles/pulse, both lesion volume and temperature distribution increased. No increase in either lesion volume or temperature distribution was observed while increasing total sonication time, but area of lethal thermal dose increased. Varying pulse repetition frequency resulted in increased lesion volume and temperature distribution and area of lethal thermal dose.

Parameter Increase	Lesion Volume Increase	Focal Temperature Distribution Increase	Thermal dose area at 240 min (CEM43) Increase
Acoustic Power	No	Yes	Yes
Number of Cycles/Pulse	Yes	Yes	No
Total Sonication Time	No	No	Yes
PRF	Yes	Yes	Yes