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. 2017 Mar 16;12(3):e0173830. doi: 10.1371/journal.pone.0173830

Table 2. The association between concurrent physician-diagnosed asthma and COPD compared to COPD or asthma with all-cause, cardiovascular and respiratory mortality rates adjusted for time (calendar year), sex, and age.

Mortality rate Odds Ratio (95% Confidence Interval)
Asthma and COPD vs. asthma Asthma and COPD vs. COPD
All-cause mortality
For entire samplea 1.56 (1.55–1.58) 0.97 (0.96–0.98)
Model: age*condition (p<0.001) Age 35–49 3.24 (3.09–3.40) 1.22 (1.16–1.28)
Age 50–64 2.16 (2.05–2.28) 1.04 (0.99–1.10)b
Age 65 and older 1.43 (1.36–1.50) 0.96 (0.91–1.00) b
Model: sex*condition (p<0.001) Males 1.50 (1.48–1.53) 0.98 (0.97–1.00) b
Females 1.61 (1.60–1.63) 0.96 (0.95–0.97)
Cardiovascular-related mortality
For entire sample a 1.47 (1.45–1.49) 0.92 (0.91–0.94)
Model: age*condition (p<0.001) Age 35–49 3.32 (2.95–3.73) 1.24 (1.10–1.40)
Age 50–64 2.19 (1.93–2.49) 1.07 (0.95–1.22) b
Age 65 and older 1.38 (1.22–1.55) 0.91 (0.80–1.02) b
Model: sex*condition (p<0.001) Males 1.40 (1.36–1.45) 0.95 (0.93–0.98)
Females 1.52 (1.49–1.55) 0.89 (0.88–0.91)
Respiratory related mortality
For entire sample a 1.84 (1.81–1.88) 1.39 (1.37–1.41)
Model: age*condition (p<0.001) Age 35–49 6.26 (5.37–7.30) 1.90 (1.64–2.20)
Age 50–64 3.09 (2.62–3.64) 1.71 (1.46–2.00)
Age 65 and older 1.71 (1.46–1.99) 1.36 (1.17–1.57)
Model: sex*condition (p<0.001) Males 1.72 (1.65–1.78) 1.45 (1.40–1.49)
Females 1.95 (1.90–2.00) 1.33 (1.30–1.36)

a Statistical Model: year, age, sex without interaction term

b—non-significant (p values ≥0.05)