Table 1. Characteristics of lung transplant recipients (n = 108).
| Variable | N (%) | Neurological complications | No Neurological complications | P value | HR | 95% CI | P value |
|---|---|---|---|---|---|---|---|
| AGE AT TX | 47.6 ± 14.7 | 49.9 ± 12.3 | 45.6 ± 16.4 | .317 | 1.01 | (0.98,1.04) | .459 |
| 0–20 | 10 (9.3) | 3 | 7 | ||||
| 21–40 | 13 (12.0) | 3 | 10 | ||||
| 41–60 | 72 (66.7) | 42 | 30 | ||||
| > 60 | 13 (12.0) | 3 | 10 | ||||
| GENDER | .598 | .978 | |||||
| MALE | 66 (61.1) | 33 | 33 | ||||
| FEMALE | 42 (38.9) | 18 | 24 | 1.01 | (0.46,2.23) | ||
| BMI | 24.4 ± 5.2 | 25.2 ± 4.8 | 23.6 ± 5.4 | .218 | 0.98 | (0.91,1.06) | .649 |
| <30 | 93 (86.1) | 45 | 48 | ||||
| 31–35 | 11 (10.2) | 5 | 6 | ||||
| >35 | 2 (1.9) | 1 | 1 | ||||
| SPIROMETRY | |||||||
| FVC vol. | 2.0 ± 0.7 | 2.0 ± 0.8 | 2.0 ± 0.7 | .959 | 0.60 | (0.32,1.13) | .097 |
| FVC% | 47.1 ± 15.7 | 46.0 ± 16.4 | 48.2 ± 15.0 | .361 | 0.97 | (0.94,1.00) | .047 |
| FEV1 vol. | 1.3 ± 0.7 | 1.3 ± 0.8 | 1.3 ± 0.6 | .869 | 0.70 | (0.38,1.30) | .246 |
| FEV1% | 39.1 ± 19.4 | 39.0 ± 21.0 | 39.3 ± 17.9 | .547 | 0.98 | (0.96,1.01) | .162 |
| FV1%/FVC | 63.8 ± 23.2 | 64.2 ± 23.3 | 63.5 ± 23.4 | .931 | 1.00 | (0.98,1.02) | .948 |
| TYPE TX | .751 | .723 | |||||
| BILATERAL | 65 (60.2) | 32 | 33 | ||||
| UNILATERAL | 43 (39.8) | 19 | 24 | 1.15 | (0.53,2.51) | ||
| HOSPITAL STAY | |||||||
| ICU | 32.0 ± 35.6 | 49.5 ± 40.7 | 16.4 ± 20.5 | < .001(*) | 1.01 | (1.00,1.02) | .003 |
| WARD | 18.0 ± 12.6 | 18.0 ± 13.6 | 17.9 ± 11.7 | .863 | 0.88 | (0.83,0.93) | < .001 |
| TOTAL | 50.0 ± 34.0 | 67.6 ± 37.4 | 34.3 ± 20.6 | < .001(*) | 1.01 | (1.00,1.02) | .077 |
| PERIOPERATIVE PERIOD | |||||||
| ISCHEMIC TIME | 312.5 ± 92.6 | 328.9 ± 76.2 | 297.6 ± 103.8 | .023 (*) | 1.00 | (0.99,1.01) | .715 |
| <2 h | 3 (2.8) | 0 | 3 | ||||
| 2–4 h | 17 (15.7) | 5 | 12 | ||||
| 4–6 h | 66 (61.1) | 35 | 31 | ||||
| >6 h | 21 (19.4) | 11 | 10 | ||||
| TRANSFUSION | .005 | .943 | |||||
| yes | 80 (74.1) | 45 | 35 | 0.97 | (0.41,2.31) | ||
| no | 27 (25.0) | 6 | 21 | ||||
| TRANSFUSION number of pRBC | 1.00 | 1.05 | (0.98,1.12) | .265 | |||
| <4 | 60 (75.0) | 32 | 28 | ||||
| 4–8 | 11 (13.8) | 6 | 5 | ||||
| >8 | 7 (8.8) | 4 | 3 | ||||
| ECMO | .311 | .212 | |||||
| yes | 24 (22.2) | 14 | 10 | 1.74 | (0.76,4.01) | ||
| no | 82 (75.9) | 36 | 46 | ||||
| ECMO time (min) | 188.5 ± 77.4 | 191.1 ± 69.4 | 184.0 ± 94.9 | .859 (*) | 0.99 | (0.98,1.01) | .316 |
| < 120 min | 5 (20.8) | 3 | 2 | ||||
| > 120 min | 17 (70.8) | 11 | 6 | ||||
| Operating time (min) | 288.3 ± 80.5 | 310.3 ± 76.1 | 267.7 ± 79.6 | 0.010(*) | 1.00 | (0.99,1.01) | .417 |
| TX INDICATION | .903 | .977 | |||||
| COPD | 36 (33.3) | 18 | 18 | ||||
| IPF | 36 (33.3) | 18 | 18 | 0.84 | (0.33,2.13) | ||
| PHTN | 8 (7.4) | 3 | 5 | 0.93 | (0.20,4.24) | ||
| CF | 11 (10.2) | 4 | 7 | 0.62 | (0.14,2.85) | ||
| OTHER | 17 (15.7) | 8 | 9 | 0.95 | (0.30,3.02) |
(*) Brunner-Munzel Test.
Abbreviations: BMI = Body Mass Index; CF = Cystic Fibrosis; CI = confidence interval; COPD = Chronic Obstructive Pulmonary Disease; ECMO = Extra-Corporeal Membrane Oxygenation; HR = :heart rate; IPF = Idiopathic Pulmonary Fibrosis; PHTN = Pulmonary Hypertension; pRBC = packed red blood cells.