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. 2017 Mar 16;12(3):e0174038. doi: 10.1371/journal.pone.0174038

Fig 5. Induction of tumor regression by GTL001.

Fig 5

Solid tumors were induced by subcutaneous injection of C57BL/6 mice with HPV16 E7-expressing TC-1 cells. On day 11, when tumors were at least palpable, and again on day 39, mice (10/group) were vaccinated intradermally with 10 μg of the solution formulation of GTL001, an equimolar amount of unconjugated HPV16 E7 and HPV18 E7 proteins, or placebo (PBS with 1.83 M urea). Where indicated, mice also received 25 mg imiquimod cream/ear at the vaccination site immediately and 24 h after each vaccination (days 11, 12, 39, and 40). Tumor size was measured every 2 to 3 days. (A) Median tumor volume. (B) Percent full tumor regression.