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Protein analyses (mean ± SE) using ELISA of the mice renal tissues showed increased inflammatory markers (A) IL-6 and (B) IL-1β and (C) ECM protein collagen in diabetic animals (Di) compared to wild type control mice (Co). These changes were prevented in the kidney of the diabetic mice with endothelial specific miR-146a overexpression (146aT+D: transgenic diabetic mice) [146aT: transgenic controls, *significantly different from Co, **significantly different from Di, n = 6/group]
