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Active site in the apo structure of E166H reveals a stable Lys-73–His-166 H-bond. a, H-bond interactions involving Lys-73 and His-166 in the active site. Fo − Fc omit map (purple) is drawn in mesh format and contoured at 2.0 σ. The dashed lines indicate hydrogen bonds. b, superposition of E166H active site with that of the wild-type. c, inferred protonation states for Lys-73 and His-166 to sustain the Lys-73–His-166 H-bond.
